BDBM292489 (S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 145

SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(O)C1

InChI Key InChIKey=OFBABNCAYHDFSH-KRWDZBQOSA-N

Data  3 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292489   

TargetCalcium/calmodulin-dependent protein kinase type II subunit delta/gamma(Rattus norvegicus)TBA

LigandBDBM292489((S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidi...)Copy SMILESCopy InChI

Affinity DataEC50:  6.20nMAssay Description:Inhibition of CaMK2gamma/delta in neonatal rat ventricular myocytes assessed as phospholamban phosphorylation after 4 hrs by Hoechst 33342 fluorescen...More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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